Our groups interest lies in understanding the basis of biological heterogeneity using computational approaches applied to ‘omics data in a disease context. We employ artificial intelligence (AI) and data science (DS) methods, not only to address the underlying causes of this heterogeneity, but also the interactions between different molecular ‘omics layers. We have a strong specialisation in the application area of oncology, but are also very interested in immunology and neurodegenerative diseases.
We believe that by better understanding global and local patterns in biological data, we can better differentiate the mechanistics behind biological and molecular processes from technical noise. As such, we rely on establishing close ties with experimental collaborators who are able to provide us with large scale and high dimensional datasets profiled using state of the art and exotic profiling techniques. We aim to take advantage of recent technological advances that are able to resolve single cell, spatial, temporal and genetic heterogeneity.
The group has a strong core expertise in analysis and interpretation of cancer multiomics data, with exposure to a wide number of omics layers and tumour entities. We are in particular very interested in understanding the heterogeneous patient response to drugs and are interested in accurate classification of tumour entities, patient specific molecular drivers, tumour microenvironment and TILs, tumour evolution and heterogeneity, and germline predisposing factors.
Naveed Ishaque, Ph.D.
Group leader at BIH Center for Digital Health
Park, J.*, Choi, W.*, Tiesmeyer, S., Long, B., Borm, L.E., Garren, E., Nguyen, T.N., Codeluppi, S., Schlesner, M., Tasic, B., Eils, R.§ & Ishaque, N.§ (2019). Segmentation-free inference of cell types from in situ transcriptomics data. bioRxiv, doi: 10.1101/800748
Mallm, J.-P.*, Iskar, M.*, Ishaque, N.*, Klett, L.C., Kugler, S.J., Muino, J.M., Teif, V.B., Poos, A.M., Großmann, S., Erdel, F., Tavernari, D., Koser, S.D., Schumacher, S., Brors, B., König, R., Remondini, D., Vingron, M., Stilgenbauer, S., Lichter, P., Zapatka, M., Mertens, D.§ & Rippe, K.§ (2019). Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology, 22;15(5):e8339. doi: 10.15252/msb.20188339
Smits, M., Zoldan, K., Ishaque, N., Gu, Z., Jechow, K., Wieland, D., Conrad, C., Eils, R., Fauvelle, C., Baumert, T.F., Emmerich, F., Bengsch, B., Neumann-Haefelin, C., Hofmann, M., Thimme, R. & Boettler, T.§ (2019). Follicular T helper cells shape the HCV-specific CD4 T cell repertoire after viral elimination. The Journal of Clinocal Investigation, 3;130(2):998-1009. doi: 10.1172/JCI129642
Ishaque, N.*, Abba, M.L.*, Hauser, C., Patil, N., Paramasivam, N., Huebschmann, D., Leupold, J.H., Balasubramanian, G.P., Kleinheinz, K., Toprak, U.H., Hutter, B., Benner, A., Shavinskaya, A., Zhou, C., Gu, Z., Kerssemakers, J., Marx, A., Moniuszko, M., Kozlowski, M., Reszec, J., Niklinski, J., Eils, J., Schlesner, M., Eils, R., Brors, B. & Allgayer, H.§ (2018). Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer. Nature Communications, 9(1), 4782. doi: 10.1038/s41467-018-07041-z
Wegert, J.*, Ishaque, N.*, Vardapour, R., Geörg, C., Gu, Z., Bieg, M., Ziegler, B., Bausenwein, S., Nourkami, N., Ludwig, N., Keller, A., Grimm, C., Kneitz, S., Williams, R.D., Chagtai, T., Pritchard-Jones, K., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Acha, T., O'Sullivan, M.J., Bode, P.K., Niggli, F., Tytgat, G.A., van Tinteren, H., van den Heuvel-Eibrink, M.M., Meese, E., Vokuhl, C., Leuschner, I., Graf, N., Eils, R., Pfister, S.M., Kool, M.§ & Gessler, M.§ (2015). Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell, 9;27(2):298-311. doi: 10.1016/j.ccell.2015.01.002
*these authors contributed equally
§corresponding author
The headline and subheader tells us what you're offering, and the form header closes the deal. Over here you can explain why your offer is so great it's worth filling out a form for.
Remember:
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Feature Title
Lorem ipsum dolor sit amet
Consectetur adipiscing elit
Integer ornare lectus ut arcu
Tincidunt porttitor
Congratulations Christian!!! Researchers today often do not look through the microscope themselves: With the vast number of cells, tissue sections and tumor samples, there is simply too much for
Charité CIO Martin Peuker is driving digitization in the healthcare sector with the Health Data Platform. The jury awards him 1st prize in the Public Sector category for his outstandig achievment.
We are pleased to present our recent achievements in building the Human Cell Atlas of the Pancreas on single-cell resolution. Due to its high autolytic activities, the pancreas is a very challenging
Professor Dominik Niopek, Department of Biology at the TU, has been awarded the "Life Sciences Bridge - Aventis Foundation Postdoctoral Award" research prize sponsored by the Aventis Foundation. The
The Hub for Innovations in Digital Health (HiDiH) brings together two independent sites of excellent research and development in Berlin and in Heidelberg. HIDIH’s major branch in Berlin is the Center for Digital Health at the Charité and the Berlin Institute of Health (BIH).
If we caught your attention, you are interested in our work and would like to get in touch with us, please contact us via info@hidih.org