We are pleased to announce our novel computational model for reducing off-target effects in CRISPR-Cas9 approaches: The manuscript Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity by Aschenbrenner et al. got recently accepted and will be published in Scientific Advances.
Please see also: https://www.bihealth.org/en/notices/fine-tuning-gene-scissors-computer-model-for-adjusting-crispr-cas9-enables-more-precise-cuts-in-the-genome/
Aschenbrenner, S., Kallenberger, S., Hoffmann, M. D., Huck, A., Eils, R. & Niopek, D. (2020). Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity. Science Advances, 6(6), doi:10.1126/sciadv.aay0187
