Research Systems Medicine (HD)

Systems Medicine Overview

Heidelberg

We investigate pathomechanisms of diseases to improve diagnostics and treatment protocols based on mathematical modeling. Especially, we are working on quantitative descriptions of cellular pathways involved in cancer to support the development of improved therapeutic strategies in oncology. Inspired by the motto “semper apertus” of our university, we are always open for exchange and collaborations with other research groups across disciplines to move towards a functional understanding in pathophysiology and translational medical research.

The systems medicine team is dedicated to applications of mathematical modeling in medicine and cellular biology. Our aim is to understand functional aspects of signal transduction systems in cells with focus on cancer research. To this end, we combine different types of mathematical models with biological experiments or clinical data. To calibrate models, we apply experimental methods for protein quantification, microscopy as well as sequencing techniques. In particular, we perform live-cell imaging to quantify processes in single cells and capture heterogeneity in cell populations. Recently, we developed a microscopy platform for automated live-cell imaging and perfusion with chemotherapeutic drugs called CytoScanner. Using this platform and algorithms from the field of machine learning, we want to optimize administration schedules of chemotherapeutic drugs.

Dr. med. Dr. rer. nat. Stefan M. Kallenberger was educated as physician and physicist and works in the areas of systems medicine and systems biology. He is a member of the Hub for Innovations in Digital Health at Heidelberg University and the National Center for Tumor Diseases. His scientific work covers applications of mathematical models for understanding biochemical pathways, characterizing pathomechanisms, and for improving the early detection of diseases.

Dr. Dr. Stefan Kallenbeger

Group leader at BioQuant-Zentrum

BioQuant-Zentrum BQ054

Im Neuenheimer Feld 267

69120 Heidelberg

stefan.kallenberger@bioquant.uni-heidelberg.de

Dr. Nelida López Palau

Postdoctoral researcher

BioQuant-Zentrum BQ054

Im Neuenheimer Feld 267

69120 Heidelberg

nelida.lopez-palau@bioquant.uni-heidelberg.de

Pablo Naranjo

Doctoral student

BioQuant-Zentrum BQ054

Im Neuenheimer Feld 267

69120 Heidelberg

pablo.naranjo@bioquant.uni-heidelberg.de

Caroline Hess

Master student

BioQuant-Zentrum BQ054

Im Neuenheimer Feld 267

69120 Heidelberg

caroline.hess@bioquant.uni-heidelberg.de

Judith Hesse

M.D. student

BioQuant-Zentrum BQ054

Im Neuenheimer Feld 267

69120 Heidelberg

judith.hesse@med.uni-heidelberg.de

Selected publications

Adam L, Stanifer M, Springer F, Mathony J, Brune M, Di Ponzio C, Eils R, Boulant S, Niopek D^#, Kallenberger SM^#. Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells. Sci Signal. 2023;16: eabl8266. (*shared first authors, ^#corresponding authors)

Klein P*, Kallenberger SM*, Roth H, Roth K, Ly-Hartig TBN, Magg V, Aleš J, Talemi, SR, Qiang Y, Wolf S, Oleksiuk O, Kurilov R, Di Ventura B, Bartenschlager R, Eils R, Rohr K, Hamprecht FA, Höfer T, Fackler OT, Stoecklin G, Ruggieri A. Temporal control of the integrated stress response by a stochastic molecular switch. Science Advances 2022, 8, eabk202, (*shared first authors)

Schmidt C, Benda S, Kraft P, Wiedmann F, Pleger S, Büscher A, Thomas D, Wachter R, Schmid C, Eils R, Katus HA, Kallenberger SM. Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation. Clin Res Cardiol 2021

Aschenbrenner S*, Kallenberger SM*, Hoffmann MD, Huck A, Eils R, Niopek D. Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity. Science Advances 2020;6:eaay0187, (*shared first authors)

Starkuviene V*, Kallenberger SM*, Beil N, Lisauskas T, Schumacher BS-S, Bulkescher R, et al. High-Density Cell Arrays for Genome-Scale Phenotypic Screening. SLAS Discov. 2019;24: 274–283, (*shared first authors)

Maier LJ*, Kallenberger SM*, Jechow K, Waschow M, Eils R, Conrad C. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Molecular Systems Biology 2018;14:e8238, (*shared first authors)

Kallenberger SM, Unger AL, Legewie S, Lymperopoulos K, Klingmüller U, Eils R, et al. Correlated receptor transport processes buffer single-cell heterogeneity. PLoS Comput Biol. 2017;13: e1005779.

Kallenberger SM, Schmid C, Wiedmann F, Mereles D, Katus HA, Thomas D, et al. A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation. PloS One. 2016;11: e0163621.

Kallenberger SM*, Schmidt C*, Dechent P, Forster C, von Steinbüchel N, Wüstenberg T, et al. Separating fusion from rivalry. PloS One. 2014;9: e103037. doi:10.1371/journal.pone.0103037, (*shared first authors)

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R. Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Science Signaling 2014;7:ra23 ("Editors' Choice" in Science Vol 343, 2014),

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